Recently, Ph.D. student Bo Cheng from BEBC
has published his first author paper in International Journal of Physics of Life Reviews entitled " Energetics: An emerging frontier in cellular
mechanosensing ".
The paper has reviewed how cells sense the substrate stiffness. Our
recent review highlighted a range of theoretical models and simulations that have been proposed to answer this important question. In response to this
review, three leading groups in the field noted some important omissions not
only from our review itself but also from the field. These groups noted,
correctly, that much of our understanding of cellular mechanosensing arises from models that take advantage
of equilibrium thermodynamics, and that this is inappropriate because living
cells are never in thermodynamic equilibrium. In this response, we highlight
some promising research aimed at resolving this conundrum.
The work is under the guidance of Professor Min Lin, Guoyou Huang, Yuhui Li, Baohua Ji, Guy
M. Genin, Vikram S. Deshpande, Tian Jian Lu.
Artical online:https://www.sciencedirect.com/science/article/pii/S1571064517301422