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Congratulations to Minli You for his recent work published in ACS nano

2017/06/01      view:

Recently, Ph.D. student Minli You from BEBC has published his research paper in ACS Nano (IF=13.334) entitled "Household Fluorescent Lateral Flow Strip Platform for Sensitive and Quantitative Prognosis of Heart Failure Using Dual-Color Upconversion Nanoparticles ". This paper has now been selected to highlight by American Chemical Society (ACS) Office of Public Affairs’ Weekly PressPac.

 

Heart failure (HF) is the end-stage of cardiovascular diseases, arousing about 35% risk of death in the first year after diagnosis and more than 50% patients readmitted to the hospital within 6 months of discharge. Prognosis of HF at home is of vital importance to prevent adverse cardiac events and decrease readmission rate. Now, we have developed a new test strip that could potentially allow patients to do this at home for the first time.

 

Antigens called ST2 and BNP are good indicators of HF and how it’s progressing. But currently, analyzing the levels of these biomarkers requires trained personnel and sophisticated lab equipment. We wanted to devise a simple test to enable doctors and patients to carry out the same analysis at the office or at home. Therefor, a fluorescent paper-based test was developed that requires only a small blood sample of 10 microliters. A green dot glows on the strip if ST2 is present in the sample, and a blue dot glows if it contains BNP. The colors’ intensities increase with concentration, which indicates a person’s heart failure is likely becoming worse. A smartphone app can analyze the readout and send the results to the patient’s doctor, who can adjust the patient’s treatment accordingly. Testing 38 serum samples from people with heart failure showed that the paper test closely matched conventional techniques.

 

The work is under the guidance of Professor Feng Xu and vice Professor Min Lin and cooperated with Mechanical Engineering School, the First and Second Affiliated Hospital of Xi’an Jiaotong University. The co-authors of the paper include Yan Gong, Shurui Wang, Professor Ang Li, Lingyu Ji, Haoxiang Zhao, Kai Ling, Doctor Ting Wen, Yuan Huang, Professor Dengfeng Gao, Qiong Ma, Professor Tingzhong Wang, Professor Aiqun Ma and Professor Xiaoling Li.


Article link: http://pubs.acs.org/doi/abs/10.1021/acsnano.7b02466