Recently, young teachers from BEBC were invited
to attend the TERMIS-AP 2016 meeting in New Taipei City, Taiwan.
The efforts of the past organizing
committees and scientific committees have successfully established TERMIS-AP as
the premier conference for the leading community of tissue engineering and
regenerative medicine technologies. The objective of this international
conference is to provide an open discussion for researchers, either from
academia, healthcare or industry, to share their experiences and achievements.The main theme of TERMIS-AP 2016 is "Personalized
Medicine through Tissue Engineering and Regenerative Medicine" consisting
of various sub-themes including basic & translational researches and
clinical trials of biomaterials, nanotechnology, stem cells, cell therapy,
tissue engineering and advanced therapy medicinal products to provide a
comprehensive coverage of diverse topics on current regenerative medicine.
Student and Young Investigator Section Oral
Award 1st Place was awarded to Guorui Jin, a young teacher from
BEBC, for the paper entitled “Conjugated Polymer Nanodots as Ultrastable
Long-Term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin
Regeneration”.
Stem cell-based therapies hold great
promise in providing desirable solutions for diseases that cannot be
effectively cured by conventional therapies. To maximize the therapeutic
potentials, advanced cell tracking probes are essential to understand the fate
of transplanted stem cells without impairing their properties. Herein,
conjugated polymer (CP) nanodots are introduced as noninvasive fluorescent
trackers with high brightness and low cytotoxicity for tracking of mesenchymal
stem cells (MSCs) to reveal their in vivo behaviors. As compared to the most
widely used commercial quantum dot tracker, CP nanodots show significantly
better long-term tracking ability without compromising the features of MSCs in
terms of proliferation, migration, differentiation, and secretome. Fluorescence
imaging of tissue sections from full-thickness skin wound-bearing mice
transplanted with CP nanodot-labeled MSCs suggests that paracrine signaling of
the MSCs residing in the regenerated dermis is the predominant contribution to
promote skin regeneration, accompanied with a small fraction of endothelial
differentiation. The promising results indicate that CP nanodots could be used
as next generation of fluorescent trackers to reveal the currently ambiguous
mechanisms in stem cell therapies through a facile and effective approach.
Congratulations to Dr. Guorui
for his award from TERMIS!
